Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

我国高校知识产权信息服务现状、困境及对策     

杜娟娟  张柏秋 《图书情报工作》2019,63(23):44-51

[目的/意义] 知识产权是经济、科技和文化实力的重要体现，已经成为各国竞相争夺的战略性资源。在建设知识产权强国背景下，急需提升高校知识产权信息服务的能力和水平，支撑高校科技创新和"双一流"建设。[方法/过程] 通过对高校知识产权信息服务工作的现状进行分析，总结高校开展知识产权信息服务工作面临的问题，并提出解决对策。[结果/结论] 针对高校知识产权信息服务面临的困境，提出改变科研评价导向，加强知识产权信息资源建设，构建知识产权信息服务标准体系，加大人才培养力度，贯通产学研全链条，有效运用大数据、人工智能技术的建议。  相似文献   

北京张坊地区中上元古界中岩溶发育与构造作用     

刘建明  张玉修  曾璐  琚宜文  芮小平  乔小娟 《中国科学院大学学报》2019,36(2):208-217

张坊岩溶地貌是中国北方岩溶类型的典型代表。分析张坊地区的地层展布与构造变形，探讨地层-构造演化与岩溶发育的关系。研究区主要出露近水平的中上元古界碳酸盐岩夹细碎屑岩和硅质岩，主要经历印支期（或更早期）伸展状态下的固态流变变形、燕山期的逆冲-褶皱变形和房山岩体期后的伸展变形等多期次构造演化，造就了研究区复杂的褶皱、断裂、构造裂隙和岩溶地貌特征。大型溶洞的发育主要与中上元古界的岩性-地层展布、中生代的逆冲断裂和新生代的伸展断裂等地质作用有关。在多阶段沉积-变形等地质作用控制下，发育了中元古代、古生代、中生代和新生代4期古岩溶，形成构造抬升侵蚀溶蚀、构造反转溶蚀冲蚀和多次抬升溶蚀侵蚀等3种主要溶洞发育类型。  相似文献   

Quality flaw prediction in Spanish Wikipedia: A case of study with verifiability flaws     

Edgardo Ferretti  Leticia Cagnina  Viviana Paiz  Sebastián Delle Donne  Rodrigo Zacagnini  Marcelo Errecalde 《Information processing & management》2018,54(6):1169-1181

In this work, we present the first quality flaw prediction study for articles containing the two most frequent verifiability flaws in Spanish Wikipedia: articles which do not cite any references or sources at all (denominated Unreferenced) and articles that need additional citations for verification (so-called Refimprove). Based on the underlying characteristics of each flaw, different state-of-the-art approaches were evaluated. For articles not citing any references, a well-established rule-based approach was evaluated and interesting findings show that some of them suffer from Refimprove flaw instead. Likewise, for articles that need additional citations for verification, the well-known PU learning and one-class classification approaches were evaluated. Besides, new methods were compared and a new feature was also proposed to model this latter flaw. The results showed that new methods such as under-bagged decision trees with sum or majority voting rules, biased-SVM, and centroid-based balanced SVM, perform best in comparison with the ones previously published.  相似文献   

Rethinking participation in the Aarhus as European Capital of Culture 2017 project     

Leila Jancovich  Louise Ejgod Hansen 《Cultural Trends》2018,27(3):173-186

This paper examines the relationship between cultural participation and regional development with reference to the European Capital of Culture in 2017. From the bidding stage, Aarhus 2017 claimed it put “participation” at the heart of its strategic plans, through consultation at roadshows and exhibitions. In addition, it aspired to use culture as a catalyst for development not only in the city of Aarhus but across the region of Central Denmark. This paper, therefore, examines how participation is defined and implemented to address regional development in the Aarhus 2017 process through textual analysis of documentation from Aarhus 2017 and delivery partners as well as over 20 interviews with managers and participants involved in a range of 2017 projects. The paper argues against the common prioritisation of urban and professional cultural institutions and makes the case for decentralised cultural provision that supports both amateurs and professionals through a regional networked structure.  相似文献   

Paternal support for child sexual abuse victims: A qualitative study     

《Child abuse & neglect》2019

BackgroundThe current state of knowledge regarding the role of non-offending fathers in supporting their sexually abused children is very scarce.ObjectiveThe objective of this study is to further our understanding of fathers’ roles following disclosure of their children’s sexual abuse (SA) by evaluating fathers’ perceptions of the impact of disclosure on their involvement and support of their children.Participants and methodThis qualitative study relies on individual semi-structured interviews conducted with 17 fathers of allegedly abused children.ResultsInductive thematic analysis first highlighted that some reported a period of disengagement from the child during which they put into question their role and attitudes, followed by a period of re-involvement. This period of difficulties experienced by some fathers in regard to their involvement towards their children was due to either their own important psychological distress, their ambivalence towards their child or even because of feelings of uneasiness experienced during physical contact with them. Despite this, findings indicate the presence of thoughts and attitudes that suggest children are a source of concern for fathers. The four forms of abuse-specific support previously observed among mothers (believing the child, seeking out professional services, protecting him/her from the offender, supporting him/her emotionally) were also observed among fathers. In accordance with the activation theory, a form of support specific to fathers, namely, encouraging the child to open up to and explore the world outside the family, thereby, fostering the child’s self-esteem development, was observed and constitutes a relevant finding.ConclusionClinical and empirical implications are discussed.  相似文献   

News You Can Use or News That Moves?     

Lauren Kogen 《Journalism Practice》2019,13(1):1-15

This study investigates how journalists covering international humanitarian crises make decisions regarding what types of information to include in stories. Specifically, the inclusion/exclusion of solutions-oriented information is addressed, since crises represent a key time during which the potential for international engagement is discussed in the mainstream media. Interviews with journalists covering hunger crises in Africa reveal an internal tension between maintaining a neutral, unbiased position and writing in a way that supports engagement and action. Ironically, perhaps, journalists find that including solutions-oriented information amounts to unethical and biased coverage, despite the fact that inclusion of solutions to social problems is an accepted and institutionalized aspect of the US news media’s mandate to the public. Reasons for this seeming contradiction are discussed, and I argue that solutions-oriented information not only can be included without demonstrating bias, but that it ought to be included to support ethical coverage that properly informs citizens about potential paths for political engagement.  相似文献   

Information retrieval in the workplace: A comparison of professional search practices     

Tony Russell-Rose  Jon Chamberlain  Leif Azzopardi 《Information processing & management》2018,54(6):1042-1057

Legal researchers, recruitment professionals, healthcare information professionals, and patent analysts all undertake work tasks where search forms a core part of their duties. In these instances, the search task is often complex and time-consuming and requires specialist expertise to identify relevant documents and insights within large domain-specific repositories and collections. Several studies have been made investigating the search practices of professionals such as these, but few have attempted to directly compare their professional practices and so it remains unclear to what extent insights and approaches from one domain can be applied to another. In this paper we describe the results of a survey of a purposive sample of 108 legal researchers, 64 recruitment professionals and 107 healthcare information professionals. Their responses are compared with results from a previous survey of 81 patent analysts. The survey investigated their search practices and preferences, the types of functionality they value, and their requirements for future information retrieval systems. The results reveal that these professions share many fundamental needs and face similar challenges. In particular a continuing preference to formulate queries as Boolean expressions, the need to manage, organise and re-use search strategies and results and an ambivalence toward the use of relevance ranking. The results stress the importance of recall and coverage for the healthcare and patent professionals, while precision and recency were more important to the legal and recruitment professionals. The results also highlight the need to ensure that search systems give confidence to the professional searcher and so trust, explainability and accountability remains a significant challenge when developing such systems. The findings suggest that translational research between the different areas could benefit professionals across domains.  相似文献   

工作资源对高校图书馆员敬业度影响机制的实证研究     

康超群  杨晴 《图书情报工作》2019,63(17):69-76

[目的/意义]探讨工作资源对高校图书馆员敬业度的影响与机制，以期为高校图书馆实施人力资源管理和提升图书馆员的敬业度提供参考。[方法/过程]选取湖南各高校图书馆的358名馆员为研究对象，考察工作资源对高校图书馆员敬业度的预测作用以及心理资本与组织承诺在两者之间的中介作用。[结果/结论]描述性统计与差异分析、相关分析和逐步回归分析的结果表明，不同性别的高校图书馆员在组织承诺量表得分上存在显著性差异，男性馆员组织承诺得分显著高于女性，不同性别馆员在其余得分上均不存在显著性差异。不同婚姻、年龄、学历、职位、职称者在各量表得分上均不存在显著性差异。高校图书馆员工作资源、心理资本、组织承诺与敬业度的两两相关都达到统计显著性水平。工作资源对高校图书馆员的敬业度具有正向预测作用，心理资本和组织承诺能够在工作资源对高校图书馆员敬业度的影响中起部分中介作用。丰富高校图书馆员工作资源，增进其组织支持感，增强其心理资本和组织承诺，是促进高校图书馆员敬业度提升的有效路径。  相似文献   

An extension of the technology acceptance model in the big data analytics system implementation environment     

Surabhi Verma  Som Sekhar Bhattacharyya  Saurav Kumar 《Information processing & management》2018,54(5):791-806

Research on the adoption of systems for big data analytics has drawn enormous attention in Information Systems research. This study extends big data analytics adoption research by examining the effects of system characteristics on the attitude of managers towards the usage of big data analytics systems. A research model has been proposed in this study based on an extensive review of literature pertaining to the Technology Acceptance Model, with further validation by a survey of 150 big data analytics users. Results of this survey confirm that characteristics of the big data analytics system have significant direct and indirect effects on belief in the benefits of big data analytics systems and perceived usefulness, attitude and adoption. Moreover, there are mediation effects that exist among the system characteristics, benefits of big data analytics systems, perceived usefulness and the attitude towards using big data analytics system. This study expands the existing body of knowledge on the adoption of big data analytics systems, and benefits big data analytics providers and vendors while helping in the formulation of their business models.  相似文献